1. Twitpic | 1,236,828 |
| 2. Tweetdeck | 285,864 |
| 3. Digsby | 233,472 |
| 4. Twittercounter | 212,200 |
| 5. Twitterfeed | 149,812 |
| 6. Twitterholic | 147,164 |
| 7. Twhirl | 143,333 |
| 8. Twitturly | 88,793 |
| 9. Twtpoll | 74,154 |
| 10. Retweetist | 60,051 |
| 11. Tweepler | 51,304 |
| 12. Hellotxt | 45,754 |
| 13. Twitdom | 45,411 |
| 14. Tweetscan | 44,463 |
| 15. Tweetburner | 41,754 |
| 16. Tweetvisor | 31,621 |
| 17. Twittervision | 30,708 |
| 18. Twitterfall | 29,592 |
| 19. Monitter | 25,433 |
| 20. Twibs | 17,168 |
| 21. Twistori | 16,229 |
| 22. Twitbin | 14,986 |